Fillers: “off-label” use

Evolence, a relatively new injection material,  is manufactured by  Ortho-McNeil-Janssen Pharmaceuticals, Inc.,  and received  FDA approved almost a year ago.  Now available in the US, it is another choice to patients for treating wrinkles.   It is currently not approved for use in the lips.

Other injection materials include hyaluronic acid (Restylane ®, Juvéderm ®), hydroxyapitite (Radiesse ®), autologous fat (fat from your own body), and other collagen products (Zyderm ®, Zyplast ®, Hylaform ®, Cosmoplast ®).  Many are FDA approved for injection into the lip area.

The Evolence  collagen is sourced from porcine (pig) tendons.   It is cross-linked using a patented technology using D-Ribose a natural sugar.   It has reportedly been injected for “off-label” use, or use not approved by the FDA.  According to studies, complications of non-approved use when injected into the lips, the results have a higher incidence of nodule (little lumps) formation and although less common, are the complications of necrosis or dead tissue.



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